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Patients with a history of severe cutaneous or other serious delayed-type reaction (eg, drug reaction with eosinophilia and systemic symptoms or Stevens-Johnson syndrome) to an antimicrobial sulfonamide should be cautioned to maintain lifelong avoidance

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People are experimenting clinically to see if spreading doses out or gradually tapering down can help maintain weight loss. That lack of FDA approval has not stopped interest from growing

Its primary studied outcome is craving reduction, not direct weight loss