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Drug interactions The prescribing label for phentermine specifically recommends against taking it with other weight loss medications , such as semaglutide or bupropion/naltrexone
The weight loss efficacy of tirzepatide alone raises an important question that anyone considering adding phentermine should seriously contemplate: with 15-21% average weight loss as monotherapy, do you actually need a second medication
The FDA recently warned of compounded semaglutides overdosing risks
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