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6 Compounded Semaglutide (active ingredient in Ozempic) is prepared in licensed, FDA-regulated compounding pharmacies in the U.S
Of the total $6.6 billion in spending related to GLP-1s over that period, two thirds occurred just in 2024 and 2025 after OPM imposed the coverage requirement
But they were designed for insulin, not peptides, and this creates a translation challenge that confuses many researchers
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