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Open Heart , e000326
A historical cohort investigation of 29 patients with comorbid mood disorder and obesity noted that liraglutide-induced weight loss over 6 months was not associated with changes in psychiatric symptoms, although less than half of the study population completed the study period 180
For context, most peptide therapeutics approved by the FDA (semaglutide, tesamorelin, sermorelin) underwent multi-arm dose-ranging studies involving hundreds to thousands of subjects before establishing their labeled doses
42,47,49,50 Treatment Considerations for the Patient Taking a GLP-1 RA Given the multifaceted role of AT in tissue homeostasis, a comprehensive regenerative approach should be considered for patients experiencing GLP-1 RA-MWL, rather than an approach focused on volumetric correction
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