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164 The extracellular matrix secreted by senescent CAFs, as identified through single-cell RNA sequencing (scRNA-seq), is found to specifically limit the cytotoxicity of natural killer (NK) cells, thereby promoting tumor growth
Animal model research reveals remarkable efficacy in both accelerated and natural aging conditions, with XpdTTD/TTD mice (accelerated aging model) showing restoration of multiple age-related deficits including fitness, fur density, and renal function following FOXO4-DRI administration
Stress management: Chronic stress affects appetite hormones and can trigger emotional eating
The forest plot from this meta-analysis is striking
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