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Its primary functions include stimulating insulin secretion, suppressing glucagon release, and slowing gastric emptying

Shaking creates foam, denatures protein at the air-liquid interface, and reduces potency

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These processes are often coordinated through integrated nutrient-sensing and stress-signaling networks, enabling tumor cells to rebalance protein and organelle turnover, maintain redox homeostasis, and preserve metabolic flexibility under lysosomal stress [134, 135]