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NRF2 rewiring of cancer metabolism confers metabolic liabilities While the regulation of serine synthesis favors proliferation and survival, we found that not all NRF2-regulated processes are favorable
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Across the evidence base, individual risk of bias is lowest overall among randomized human trials, moderate among observational studies, and inherently high among preclinical models and narrative reviews due to indirectness, despite strong mechanistic consistency
Based on the evidence that heat-shock proteins (Hsps) can exert neuroprotective effects against oxidative stress-related injury and that nutritional antioxidants are able to upregulate Hsps in neurons, use of nutritional antioxidants such as carnitine/acetyl-L-carnitine has been advocated to counteract the oxidative stress-induced brain damage in Alzheimer's disease [67, 119]