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Anaphylaxis following a B12 injection has been documented in medical literature, particularly in patients with a sensitivity to cobalt or cobalamin compounds

According to a study published in PubMed Central (National Institutes of Health), intravenous administration of vitamin B12 provides a faster increase in B12 levels compared to oral supplementation, making it a potentially better option for patients with severe deficiency

10.1074/jbc.M110.117697 J

Cons : Needle anxiety and higher preparation burden are the two main barriers that some patients face with regard to any sort of injectable medication

Every dose you calculate from that point forward is wrong by roughly 20%