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A typical weekly research dose of 6mg (2mg three times weekly) represents approximately 0.027% of the estimated toxic dose
Theoretical risks of sustained angiogenic stimulation (promoting vascular supply to undetected pathological tissue) grow proportionally with the duration of use, as cumulative VEGF upregulation exceeds the controlled, injury-localized window intended by short-cycle research protocols
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Chawla, Thiamin Deficiency in People with Obesity, Adv
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