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Similarly, deleting AMPK1 gene altered the differentiation pathway of M-MDSCs, leading them to adopt a cytotoxic role against tumors through nitric oxide synthase 2, highlighting the central role of AMPK1 in MDSC-mediated immunosuppression

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J Hepatol 2020;72:558-577

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Such virus-induced dysbiosis triggers cytokine release with NF-B-mediated hyper-inflammatory response, and the ensuing immune dysregulation could worsen the clinical outcomes of COVID-19 240