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Interestingly, despite the lack of consistent actions of metformin in terms of metabolic profiles, treatment with the insulin sensitizer caused a complete normalization of ovarian cyclicity, pointing to a discernible reproductive effect of metformin in some PCOS conditions, in line with clinical literature 68 , although conflictive results have been reported also 69

These medicines are generally well tolerated, although gastrointestinal side effects are common during treatment initiation or dose escalation

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Those at the 4 mg dose still lost an impressive 35 pounds on average

The microbiome as a key regulator of brain, behavior and immunity: commentary on the 2017 named series