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This trial involved over 1,900 adults with obesity or who were overweight with health problems related to their weight

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Diabetologia 1995;38(1):123

It also improves insulin sensitivity and glucose disposal, which matters with IGF-1 LR3 given the hypoglycemia risk

(1992, Biochemical Journal) showed IGF-1 LR3 produced larger anabolic responses than native IGF-1 in dexamethasone-induced muscle catabolism in rats