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Common side effects of the drug include nausea, vomiting, diarrhea, constipation and indigestion
Elevated GSH enables cancer cells to resist oxidative stress, sustain proliferation, and survive anchorage-independent growth
Selenium works particularly well in combination with other antioxidants like vitamin E
The released Fe 3+ exhausted intracellular GSH via Fenton reaction, boosting ROS production by TCPP-mediated PDT (Figures 2B, C)
When activated, MC1R triggers a signaling cascade: MC1R activation cAMP increase cAMP activates MITF (master melanocyte transcription factor) MITF upregulates tyrosinase and related enzymes Pheomelanin production shifts to eumelanin production This last point is the key insight
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