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Concretely, GPX4 uses GSH as the substrate to reduce phospholipid hydroperoxides (PLOOHs) to hydroxyl derivatives (PLOHs), and oxidizes GSH to GSSH, therefore alleviating the damage of oxidative stress to tumor cells (Stockwell, 2022)
10.3389/fphar.2018.00921 Front
Fight Aging
Every researcher should understand this relationship because it is the single concept that underlies every dose chart on this page
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