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In animal-model work, NNMT inhibition with 5-Amino-1MQ has been associated with changes in adipose-tissue mass, in NAD+ pool sizes (because NNMT consumes nicotinamide that would otherwise feed the NAD+ salvage pathway), and in methyl-donor dynamics (because NNMT consumes S-adenosylmethionine)
PMID: 35460727 Int J Biol Sci 2022 Jan 1;18(2):717-730
Instead of burning glucose, cells turn to fatty acids and ketones, such as -hydroxybutyrate (-HB)
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