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Clearance = timed urine volume (mL/min) (urine concentration / plasma concentration) Both an accurately timed urine sample and a blood sample must be collected

Two different commercial inactivated yeasts (IDY-1: Pure-Lees Longevity and IDY-2: Noblesse) and an experimental (IDY-3: Antiox-1), all provided by Lallemand Inc (Montreal, Canada), were used

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However, recent studies demonstrated that it is possible to re-sensitize tumors using a combination of molecules specifically reverting the aberrant DNA methylation in cancer cells (through drugs inhibiting DNA methyltransferase activity) and cytotoxic drugs (Plumb et al., 2000

For the clinical application of SGD, there is currently a lack of high-quality large-scale RCTs, which is worthy of further research