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Skipping titration, or starting at a higher dose because someone in a group chat said it works faster, is one of the most common causes of severe nausea, vomiting, and dehydration

Weeks 25-52+: Maintenance and continued slow progress

Closest Analog: Cagrilintide + Semaglutide REDEFINE 1 (Garvey et al., NEJM 2025) is the only Phase 3 trial of an amylin + incretin co-administered combination in adults without diabetes

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More people who received semaglutide lost at least 5% of their starting body weight compared to those who received a placebo (86% vs 32%)