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6-BPPI was an effective antagonist of the GLP-1R but was inactive on a chimeric receptor composed of the ectodomain of the gastric inhibitory polypeptide receptor (GIPR) fused to the 7TM domains of the GLP-1R

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They received the maximum tolerated dose of Zepbound (10 mg or 15 mg) or Wegovy (1.7 mg or 2.4 mg) for 72 weeks

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Bioactive compounds, such as those found in sunflower seeds, have also been used to reduce glucose levels and control insulin resistance and production

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