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As a dual agonist, tirzepatide (GLP-1 + GIP) continues to outperform semaglutide in weight loss and metabolic control, setting a new bar for combination therapies
To see whether an elevation in H 2 S levels affected persulfidation, we investigated cardiac ischaemia, when the lack of oxygen and consequent reduction of the mitochondrial Coenzyme Q pool prevents the oxidation of H 2 S by mitochondrial SQOR and is thus thought to lead to the accumulation of H 2 S 12,13
Repeated dosing doesn't appear to cause significant pituitary tachyphylaxis (loss of response) over standard treatment periods
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