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Novo Nordisk's oral semaglutide (Rybelsus) is approved for type 2 diabetes but not for obesity, and its SNAC-dependent formulation imposes the fasting and water restrictions that orforglipron avoids

Most of these new drugs come in the form of injections that you give yourself daily or weekly

Newer Therapies: Dual agonists like Tirzepatide also show high efficacy and safety in fasting populations

10.1182/blood-2002-08-2548 98 LiJ

From there, you can chat with a clinician about options like magnesium glycinate or non-hormonal prescription medications that target vasomotor symptoms like night sweats (such as Veozah or certain SSRIs/SNRIs)