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[Crossref] Isotalo PA, Wells GA, Donnelly JG (2000) Neonatal and fetal methylenetetrahydrofolate reductase genetic polymorphisms: an examination of C677T and A1298C mutations

Preeclampsia, placental rupture, spontaneous abortion, and miscarriage are all linked to elevated plasma homocysteine levels

doi: 10.3389/fimmu.2026.1761421 Received 05 December 2025 Revised 31 January 2026 Accepted 04 February 2026 Published 24 February 2026 Volume 17 - 2026 Edited by Qiushui He, University of Turku, Finland Reviewed by Jan Josef Stepan, Charles University, Czechia Namrata Anand, University of Chicago Medical Center, United States Updates Copyright 2026 Liu, Lu, Bai, Han, Zha and Jiang

Topical forms work well for localized skin applications but have limited penetration depth

Most products provide 500 to 1000mcg of B12, despite the Recommended Daily Allowance (RDA) being significantly lower