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Due to its anti-oxidants, anti-coagulants, anti-inflammatory properties, and bioactive substances like melittin and phospholipase BV is mainly used to treat many inflammatory disorders such as arthritis, cancer, diseases of the nervous system, heart and blood system abnormalities, skin diseases, and others (Khalil et al., 2021)

Studies on mitochondria-derived peptides and their role in regulating long-term metabolic adaptation consistently point to off-cycle consolidation as a critical part of the protocol

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This approach prioritizes chronic pathway activation, particularly AMPK and antioxidant response element signaling, over acute metabolic effects