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R26 tdTomato Ms4a3 -Cre mice were generated by crossing R26 tdTomato mice with Ms4a3 -Cre mice (C57BL/6J-Ms4a3 em2(cre)Fgnx /J, The Jackson Laboratory, 036382)

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We restricted the study cohorts to patients with a diagnosis of type 2 diabetes and without use of any of the two drug classes being compared for the past 365 days, aged 18 years (65 years for Medicare), and with at least 12 months of continuous insurance enrollment before cohort entry