Benefits Beyond Weight Loss While weight reduction is often the primary goal, GLP-1 medications affect multiple systems throughout the body
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Its proposed mechanisms include the enhancement of lipid metabolism, improvement of insulin sensitivity, stabilization of hepatocyte function, and reduction of inflammation, fibrosis, and tumorigenesis
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4 In an additional post-hoc analysis, 14.1% of patients on retatrutide 9 mg and 12.0% patients on retatrutide 12 mg were completely free of knee pain at 68 weeks compared to 4.2% on placebo, based on the observed efficacy estimand data