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As expected, we found that MB07811 treatment not only reduced the body weight, fat weight, liver weight without changing food intake, but also lowered the blood glucose levels in HFD-fed mice (Fig

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In a randomized, single-blind, 24-week study, participants assigned to dual therapy of 2 mg weekly of the GLP-1 receptor agonist exenatide (Bydureon, AstraZeneca) and 10 mg daily of the SGLT2 inhibitor dapagliflozin (Farxiga, AstraZeneca) lost more weight than those taking either agent alone or those receiving dapagliflozin and metformin extended-release (Xigduo XL, AstraZeneca) or phentermine/topiramate extended-release (Qsymia, Vivus)

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They had 3 groups and nearly 2500 participants