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This imbalance can be caused by intense exercise, UV exposure, pollution, or poor diet
Its systemic distribution and versatility are why it is often studied as a complement to more locally acting compounds
Glucagon-like peptide-1 (GLP-1) receptor agonist prevents development of tolerance to anti-anxiety effect of ethanol and withdrawal-induced anxiety in rats
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(Source 8) However, it's hard to say this benefit is due to the caffeine when coffee is very high in polyphenol antioxidant compounds, which are beneficial
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