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Animal As a senolytic, FOXO4-DRI carries mechanism-specific theoretical risks discussed in the senescence literature including disruption of beneficial senescence surveillance and off-target effects on stem-cell populations that share features with senescent cells and senolytic translation from mouse to human has a history of failures

doi: 10.2337/db22-727-P 88 ChavdaVPAjabiyaJTeliDBojarskaJApostolopoulosV

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doi: 10.3233/jad-160152 35 LevineKSLeonardHLBlauwendraatCIwakiHJohnsonNBandres-CigaSet al