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The detrimental effects of low-temperature preservation of ovarian tissue encompass ROS generation, DNA fragmentation, and caspase activation, which may result in damage to granulosa and stromal cells, oocyte degeneration, and follicular attrition

10.3748/wjg.v23.i48.8465 18 FaghihiH.Mehdi RajaeiS.MehrazinH.GolabdarS.BrooksD

Similar patterns are expected with tirzepatide and retatrutide, though long-term discontinuation data for retatrutide is not yet available