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Urgent medical attention is needed for very high readings (for example, above 20 mmol/L), symptoms of hyperglycaemia (increased thirst, frequent urination, fatigue), or any signs of diabetic ketoacidosis (nausea, vomiting, abdominal pain, fruity breath odour)

This reflects the complex interaction between slowed gastric emptying (which can cause constipation) and changes in gut motility signaling (which can cause diarrhea)

Ultra-low calorie intake: Eating fewer than 1,000 calories daily, which is easy to do accidentally when appetite is dramatically suppressed, triggers metabolic adaptation that actually slows weight loss over time

Proc Natl Acad Sci USA 98:23232328 Xu C, Zhang X, Yu C, Lu G, Chen S, Xu L, Ding W, Shi Q, Li Y (2009) Proteomic analysis of hepatic ischemia/reperfusion injury and ischemic preconditioning in mice revealed the protective role of ATP5beta

R., Linkermann, A