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By scavenging ROS and bolstering endogenous antioxidant defenses, it safeguards cellular integrity, protecting DNA, proteins, and lipids from oxidative damage

The ratio of GSH to GSSG in your cells is one of the most reliable markers of oxidative stress researchers have identified

Furthermore, these nanocarriers are capable of depleting GSH levels in the tumor microenvironment to augment stress on cells and induce cell death pathways, including ferroptosis, making cancer cells sensitive to treatment Fig

Here, the nano-conjugate VEGF 121 -mesoporous silica was able to selectively deliver sunitinib tyrosine kinase inhibitor to tumor vasculature

Peer review Peer review information Nature Communications thanks the anonymous reviewers for their contribution to the peer review of this work