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Most people lose 15 to 20 percent of their body weight on semaglutide over 12 to 18 months
However, endogenous GLP-1 has an extremely short half-life due to rapid degradation by dipeptidyl peptidase-4 and renal clearance
It seems to calm inflammation rather than shut it off completely
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material becomes more available to intestinal and pancreatic receptors while at lower doses, the intestinal route provides more direct exposure to the relevant receptor locations
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