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Although Clostridia can redirect metabolic pathways to shift carbon and energy metabolism toward those with higher oxygen tolerance, such metabolic rewiring has a high probability of impairing the performance of engineered strains, resulting in a decrease in the yield of the intended target product

Current clinical trials and future studies should take into account gender-dependent factors, receptor polymorphism, and the selectivity of brain regions in order to optimize the translational potential of this strategy [114]

GLPs (glucagon-like peptide-1 receptor agonists) are medications that mimic the natural hormone, glucagon