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For GTT, injection volume was calculated as mentioned below: Food intake Mice were singly housed before the experiment in a 12 h light/dark cycle with ad libitum access to water and were fasted overnight for 12 h (9 pm9 am)
G., Verdijk, L
GLP-1 receptor agonists were originally approved for the treatment of type 2 diabetes, though given the prevalence of GLP-1 receptors in various peripheral tissues, more recent studies have started to look at additional etiologies for which GLP-1 agonists could be a feasible therapeutic option, including MASLD
These approaches have led to significant weight loss with the dual GLP-1/glucagon receptor agonist survodutide (-13.5% with the 6-mg dose at 76 weeks in a phase 3 SYNCHRONIZE-1 trial) [16] , the dual GLP-1 receptor agonist and GIP antagonist Maridebart cafraglutide (known as MariTide) (-12.3% to -16.2% across different doses at 52 weeks in a phase 2 trial) [17] or the triple GLP-1/GIP/glucagon receptor agonist retatrutide (-24.2% with the 12-mg dose at 48 weeks in a phase 2 trial) [18]
Mounjaro, as a newer entrant, offers a fresh perspective on using GLP-1 receptor agonists for weight management
