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The down-regulation of PGC-1 further inhibits the expression of downstream factors such as nuclear respiratory factor 1 and mitochondrial transcription factor A, thereby damaging the mitochondrial biosynthesis process, which is often accompanied by an increase in the oxidative stress levels [31]

Even once they have achieved a goal weight, they may still feel uncomfortable in the mirror or in clothing

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In vivo , in a murine monoiodoacetate (MIA)-induced model of OA, a single intra-articular injection of liraglutide reduced synovitis severity, whilst weekly intra-articular injections attenuated behaviour pain responses [95]

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