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52 Research has also demonstrated that ovarian cancer cells stimulate membrane cholesterol efflux from TAMs, fostering an environment that promotes tumor growth by enhancing interleukin (IL)-4-mediated reprogramming and suppressing IFN-induced gene expression

61 Extracellular lactate induces alanyl-tRNA synthetase 1 (AARS1)-dependent lactylation of nucleophosmin 1 (NPM1), leading to repression of SLC7A11 and impaired cystine metabolism, thereby facilitating ferroptotic trigger waves along tubular compartments