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A recent phase3 trial comparing tirzepatide vs semaglutide in people living with obesity (without diabetes) reported average weight loss of 20.2% with tirzepatide vs 13.7% with semaglutide over 72 weeks
Some studies suggest that using semaglutide and topiramate together may lead to better weight loss outcomes compared to using either drug alone
Metabolism is a 24-hour job
Taurine deoxycholic acid (TUDCA), loganin, and CXCL2 blocking therapy all have the effect of modulating NLRP3, and all three have also been shown to improve SCs mortality in the HG environment (58, 109, 110)
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