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Demarco,
The through-line is diversity
Both anti-diabetic treatments function by playing key modulatory roles in the incretin system
We also address patient questions about newer options, including what are peptides for weight loss, while prioritizing safety, muscle preservation, and long term metabolic health
The more open TMD in the static exendin-4 bound cryo-EM structure was associated with fewer stable peptide contacts (Supplemental Table 1), relative to GLP-1 and oxyntomodulin, however, the cryo-EM map was lower resolution, which precluded modelling of some of the binding site (top of TM6, ECL3 and ECL1)
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