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It can lead to neuropathy, megaloblastic anemia, and pernicious anemia, [2] [13] causing symptoms including fatigue, paresthesia, depression, cognitive decline, ataxia, and even irreversible nerve damage
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We found that administration of BSO to established PDX tumors with high ACTL6A expression decreased the total GSH level but exerted no impact on the glutamine or glutamate level (Fig
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The changes in GSH levels induced by such stress are instantaneous and drastic processes, while the generation and replenishment of GSH require a lengthy process, due to involving the rate-limiting indicator glutathione synthetase [43]
