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Amylin agonism drives three things: delayed gastric emptying, central satiety signaling through the area postrema, and suppression of postprandial glucagon
Many patients prescribed Ozempic are already taking metformin, which is commonly used as first-line therapy for type 2 diabetes according to NICE guidelines (although SGLT2 inhibitors may be first-line in certain cardio-renal risk groups)
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