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Signs of thyroid problems (neck swelling, difficulty swallowing, persistent hoarseness) require prompt medical review Symptoms of gallbladder disease (right upper quadrant pain, jaundice, fever) Acute kidney injury symptoms (marked reduction in urine output, swelling, confusion), which can occur secondary to severe dehydration A comprehensive clinical assessment should include review of blood glucose monitoring, assessment for anaemia (full blood count), thyroid function tests, renal function, and evaluation of nutritional status

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The interactions with the oxidative stress are resumed in figure 2

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