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The new compound they developed targeted only this brain pathway, with the pigmentation mechanism removed
In contrast, cobalamins with Co + 2 and Co + 1 ions are five- and four-coordinate, respectively, and can be converted into active forms of vitamin B12
OVX mice are widely used to model a range of human age-associated pathologies, including osteoporosis, neurodegeneration and cardiac dysfunction, as well as perimenopausal symptoms, such as depression and hot flushes [110112]
These alterations may be further exacerbated by oxidative stress and activation of profibrotic cytokines, such as transforming growth factor , ultimately contributing to the development of chronic kidney disease (82)
