The SUPRPASS-4 trial (262), involving 2002 participants with high-risk cardiovascular profiles followed for up to 104 weeks, showed no difference in 4-MACE events (cardiovascular death, myocardial infarction, stroke, and hospitalization for unstable angina) with tirzepatide compared to insulin glargine (HR 0.74
Because of societal standards, Gorfinkel says female patients in particular tend to ask for the drug to help lose a stubborn 10 or 15 pounds for cosmetic reasons
Some experts worry that broader availability to certain peptides through compounding pharmacies could expose larger numbers of patients to therapies whose long-term safety profiles remain unclear
Known for its calming effects, it can help reduce anxiety and promote a state of relaxation, making it easier to fall asleep
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