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Unlike stimulant-based cognitive enhancers that borrow energy from tomorrow to pay for today's focus, peptide nootropics like Semax, Selank, Dihexa, and P21 work by optimizing the brain's underlying neurochemistry and structural integrity, producing sustainable improvements in memory formation, information processing, mental clarity, and cognitive resilience under stress

GLP-1 agonists are promising for MASH treatment because they target multiple aspects of the disease, including fat accumulation, inflammation, and insulin resistance, which are all key factors in MASH progression

Glucagon component adds thermogenic and lipolytic effects absent from GLP-1 and tirzepatide

Long-term ablation of DMH GLP-1R resulted in hyperphagia and obesity, and blunted exendin-4-induced anorexigenic metabolic effects [68,73]

Neuron 2017;96:897-909.ArticlePubMedPMC 95