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Importantly, outside of JAK-STAT and PIK3/Akt, the GH-GHR, IGF-IGFR, IGF-IR interactions can stimulate several other different intracellular signaling cascades notably PLC/PKC and MAPK/ERK1/2 pathways (120)

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When combined with semaglutide, the results are even more significant, demonstrating weight loss of up to 17% of body weight in the same period ( 1, 2 )