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Difficulty breathing or other systemic symptoms

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The most successful treatments currently available include glucagon-like peptide-1 (GLP-1) receptor agonists (GLP-1RAs), exemplified by semaglutide (approved in 2017, $19.9 billion sales in 2023) 3 and tirzepatide (approved in 2022, $5.3 billion sales in 2023) 4

Exceeding this threshold, particularly over extended periods, may lead to adverse effects including copper deficiency, impaired immune function, and gastrointestinal disturbances