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Clinical data shows benefits fade within 2-6 months despite maintenance therapy, with only 6.2% of patients retaining any effect at 6 months in the Zubair et al

When insulin/GLP-1RA fixed-ratio combinations are compared with basal insulin, a superiority in reducing HbA1c is observed, with overall benefit also in weight neutrality or weight loss, reduced hypoglycemia risk, and reduced insulin-dose requirement [19, 25,26,27, 30, 31]

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