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Even a minor deficiency of B6 can cause a substantial down-regulation of these neurotransmitters
It is naturally present in human blood, saliva, urine, and its plasma concentration declines with age from approximately 200 ng/mL at age 20 to under 80 ng/mL after age 60
Miller et al., 2008)
Bains JS, Pasqualotto BA, Shaw CA, Curry K
Blood levels take about four weeks to settle after a step. The stomach-slowing effect that drives early nausea builds and then adapts over roughly the same window. And gut symptoms cluster at the first dose and at each increase, then ease with time on a held dose. The label waits for the last step to settle before adding the next
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