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Oral NAC was effective in preventing oxaliplatin-induced mechanical and cold allodynia in mice and significantly reduced liver, kidney, and spinal cord peroxidation, kidney protein carbonylation, and spinal IL-1b and TNF- expression induced by oxaliplatin but did not affect the antitumor activity or hematological toxicity of oxaliplatin in vivo [62]
In a randomized trial, 74 RA patients were given either 600 mg of NAC or a placebo twice daily for three months
Slyshenkov, D
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