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Incretins and their synthetic mimetics offer benefits by influencing the appetite and satiety centers in the brain, potentially resetting the bodys fat mass and body weight setpoints that are associated with the interplay between orexigenic and anorexigenic signaling pathways
Peripheral administration of liraglutide decreased preference for highly palatable foods in rats suggesting that GLP-1R mimetics may have therapeutic potential to decrease food reward (Raun et al., 2007
increase insulin sensitivity
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