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The difference seems to be that berberine increases high-glucose dependent insulin , [6,25] meaning that it's more effective when glucose is present

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The combination treatment, at a non-myeloablative dose, that was maximum tolerated by beige-nude-xid mice induced CRs in 100% of the MM.1S and OPM-2 xenografts, while 25% of mice achieved a CR in KMS-12-PE xenografts

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